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Methodology This online survey was conducted among 1,536 Canadian residents and 1,012 American residents aged 18 or older, between February 6 and 9, 2026

For example: Fatigue, unexplained weight loss, or abdominal pain may indicate liver disease or cancer Easy bruising, night sweats, or feeling full quickly (early satiety) may suggest a myeloproliferative disorder Swelling in the legs, reduced urine output, or persistent nausea may point to kidney disease In cases of very high B12 from injections (not oral supplements), some people have reported headache, nausea, diarrhea, facial flushing, or skin rash

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10.1016/s0021-9258(18)71239-8PubMed Abstract | CrossRef Full Text | Google Scholar 97 MartignoniM.GroothuisG.de KanterR